Maxima,
I remember removing the bio-balls in my wet/dry filter. It was a big leap of faith. Since that time, 20 years ago, I have embraced a low tech/more biology technique. Every method has its pros and cons which need to be dealt with. Leaving your skimmer running, imo, is not a big deal, particularly if it has been operating in a steady mode. Without knowing the specifics of your tank, it would be like shooting in the dark to give you specific advise. Only in extreme cases, as a last resort, would I break down a tank that has been set up for a year or more. In the last 30 years, all my tanks were set up to run on automatic. My job as a deep water subsea engineer would send me away from home at least 28 days at a time. Enjoy your vacation and have someone that you trust, look in on your tank. I also suggest getting a good maitenance person as a back up resource that your homesitter could talk with.
Patrick