I completely agree with Ty on the added difficulty of medication with Sand/Live Rock. It will definitely make it more difficult, but I don't mind the extra work when the majority of the time the tank should hopefully not need medication and is setting in my bedroom where I see it everyday. So I'm sticking with Sand/LR and if I have to medicate I will, then remove the Sand/LR and start over with new Sand/LR from my sump (LR only from the sump that is). The intent is that this tank will be a permanent QT versus a temporary one. We will see how this goes, if it becomes a huge chore (if I need to medicate a lot) then I may rethink my strategy. lol
I'm also going to try and be particular on where I purchase fish, this should help to reduce (not minimize) the disease risk if the vendor also QT's their fish.